Drug delivery to solid tumors by elastin-like polypeptides
نویسندگان
چکیده
منابع مشابه
Barriers to drug delivery in solid tumors
Over the last decade, significant progress has been made in the field of drug delivery. The advent of engineered nanoparticles has allowed us to circumvent the initial limitations to drug delivery such as pharmacokinetics and solubility. However, in spite of significant advances to tumor targeting, an effective treatment strategy for malignant tumors still remains elusive. Tumors possess distin...
متن کاملTargeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia.
Elastin-like polypeptides (ELPs) are biopolymers of the pentapeptide repeat Val-Pro-Gly-Xaa-Gly that undergo an inverse temperature phase transition. They are soluble in aqueous solutions below their transition temperature (T1) but hydrophobically collapse and aggregate at temperatures greater than T1. We hypothesized that ELPs conjugated to drugs would enable thermally targeted drug delivery t...
متن کاملElastin-Like Recombinamers As Smart Drug Delivery Systems.
BACKGROUND Drug delivery systems that are able to control the release of bioactive molecules and designed to carry drugs to target sites are of particular interest for tissue therapy. Moreover, systems comprising materials that can respond to environmental stimuli and promote self-assembly and higher order supramolecular organization are especially useful in the biomedical field. Objetive: This...
متن کاملExploring self-assembly behavior of elastin-like polypeptides
Aqueous solutions of commercial poly(oxyethylene) – poly(oxypropylene) – poly(oxyethylene), triblock co-polymers (PEOx – PPOy – PEOx, Pluronics©) undergo both micellization and structural arrangement as a function of increasing temperature. In the case of Pluronic F127 (PEO100 – PPO65 – PEO100), this structural arrangement is observed macroscopically as a liquid to gel transition for polymer co...
متن کاملFabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying.
The development of environmentally responsive drug carriers requires new methods for assembling stimuli-responsive nanoparticulates. This communication describes a novel application of electrospray to construct bioresponsive peptide-based particulates, which can encapsulate drugs. These particles are composed from genetically engineered elastin-like polypeptides (ELPs), a biodegradable, biocomp...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2010
ISSN: 0169-409X
DOI: 10.1016/j.addr.2010.05.004